Our claim is that so-called "Big Data" will evolve into a new era with proliferation of data from multiple sources such as massive numbers of sensors whose resolution is increasing expo- nentially, high-resolution simulations generating huge data results, as well as evolution of social infrastructures that allow for "opening up ...

Protein-protein docking is a method for predicting the protein complex structure from monomeric protein structures. Because protein structural information has been increased and the application field has been expanded to more difficult ones such as interactome prediction, a faster protein-protein docking method has been eagerly demanded. MEGADOCK is fast protein-protein ...

We propose a new hydrophobic interaction model that applies atomic contact energy for our protein---protein docking software, MEGADOCK. Previously, this software used only two score terms, shape complementarity and electrostatic interaction. We develop a modified score function incorporating the hydrophobic interaction effect. Using the proposed score function, MEGADOCK can calculate ...