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Compositional modelling of signalling pathways in timed concurrent constraint programming

Published:02 August 2010Publication History

ABSTRACT

The biological data regarding the signalling pathways often consider single pathways or a small number of them. We propose a methodology for composing this kind of data in a coherent framework, in order to be able to investigate a bigger number of signalling pathways. We specify a biological system by means of a set of stoichiometric-like equations resembling the essential features of molecular interactions. We represent these equations by a timed concurrent constraint (ntcc) language, which can deal with partial information and the time for a reaction to occur. We describe a freely available prototypical implementation of our framework.

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  • Published in

    cover image ACM Conferences
    BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology
    August 2010
    705 pages
    ISBN:9781450304382
    DOI:10.1145/1854776

    Copyright © 2010 ACM

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    New York, NY, United States

    Publication History

    • Published: 2 August 2010

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