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CRISPR/Cas9-NHEJ: action in the nucleus

Published:12 August 2018Publication History

ABSTRACT

CRISPR/Cas9-NHEJ: Action in the Nucleus (2017) is derived from an interdisciplinary creative process. This paper discusses the creation of this 210° scientific visualization, the usage of data from the worldwide Protein Data Bank, and the audio-visual presentation in an interactive dome setup. Since the topic is significant for the future of humanity, immersive experiences should be considered to convey tacit knowledge of gene-editing processes to make them approachable for the general public.

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References

  1. Helen Berman, Kim Henrick, and Haruki Nakamura. 2003. Announcing the worldwide protein data bank. Nature Structural and Molecular Biology 10, 12 (2003), 980.Google ScholarGoogle ScholarCross RefCross Ref
  2. Drew Berry. 2003. Molecular Visualizations of DNA. The Walter and Eliza Hall Institute of Medical Research. (2003). https://www.youtube.com/watch?v=OjPcT1uUZiEGoogle ScholarGoogle Scholar
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  4. Ayal Hendel, Rasmus O Bak, Joseph T Clark, Andrew B Kennedy, Daniel E Ryan, Subhadeep Roy, Israel Steinfeld, Benjamin D Lunstad, Robert J Kaiser, Alec B Wilkens, Rosa Bacchetta, Anya Tsalenko, Douglas Dellinger, Laurakay Bruhn, and Matthew H Porteus. 2015. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Nature Biotechnology 33 (June 2015), 985.Google ScholarGoogle Scholar
  5. Connor Hendrich. 2014. Non-homologous end joining. Oxford University Press Online. (2014). https://www.youtube.com/watch?v=31stiofJjYwGoogle ScholarGoogle Scholar
  6. Mikihiro Shibata, Hiroshi Nishimasu, Noriyuki Kodera, Seiichi Hirano, Toshio Ando, Takayuki Uchihashi, and Osamu Nureki. 2017. Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy. Nature Communications 8, 1 (Nov. 2017), 1430.Google ScholarGoogle ScholarCross RefCross Ref

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  1. CRISPR/Cas9-NHEJ: action in the nucleus

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            cover image ACM Conferences
            SIGGRAPH '18: ACM SIGGRAPH 2018 Posters
            August 2018
            148 pages
            ISBN:9781450358170
            DOI:10.1145/3230744

            Copyright © 2018 Owner/Author

            Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the Owner/Author.

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            Association for Computing Machinery

            New York, NY, United States

            Publication History

            • Published: 12 August 2018

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            Overall Acceptance Rate1,822of8,601submissions,21%

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