Abstract
Flow-based microfluidic biochips can be used to perform bioassays by manipulating a large number of on-chip valves. These biochips are increasingly used today for biomolecular recognition, single-cell screening, and point-of-care disease diagnostics, and design-automation solutions for flow-based microfluidics enable the mapping and optimization of bimolecular protocols and software-based valve control. However, a key problem that has not received adequate attention is chip-to-world interfacing, which requires the use of off-chip control equipment to provide control signals for the on-chip valves. This problem is exacerbated by the increase in the number of valves as chips get more complex. To address the interfacing problem, we present an efficient pin-count minimization (synthesis) problem, referred to as Synterface, which uses on-chip microfluidic logic gates and optimization based on concepts from linear algebra. We present results to show that Synterface significantly reduces pin-count and simplifies the external interface for flow-based microfluidics.
- Andrew Adamatzky and Theresa Schubert. 2014. Slime mold microfluidic logical gates. Materials Today 17, 2 (2014), 86--91.Google Scholar
Cross Ref
- Nada Amin et al. 2009. Computer-aided design for microfluidic chips based on multilayer soft lithography. In Proc. ICCD. 2--9.Google Scholar
- Howard Anton and Chris Rorres. 2013. Elementary Linear Algebra, Binder Ready Version: Applications Version. John Wiley 8 Sons.Google Scholar
- Ismail E. Araci and Stephen R. Quake. 2012. Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves. Lab on a Chip 12, 16 (2012), 2803--2806.Google Scholar
- Nirveek Bhattacharjee, Arturo Urrios, Shawn Kang, and Albert Folch. 2016. The upcoming 3D-printing revolution in microfluidics. Lab on a Chip 16, 10 (2016), 1720--1742.Google Scholar
- CF Chen et al. 2009. High-pressure needle interface for thermoplastic microfluidics. Lab on a Chip 9, 1 (2009), 50--55.Google Scholar
- Tomasz S. Czajkowski and Stephen D. Brown. 2008. Functionally linear decomposition and synthesis of logic circuits for FPGAs. IEEE Trans. CAD 27, 12 (2008), 2236--2249.Google Scholar
Digital Library
- Trung A. Dinh et al. 2015. An optimal pin-count design with logic optimization for digital microfluidic biochips. IEEE Trans. CAD 34, 4 (2015), 629--641.Google Scholar
Digital Library
- Lynh Huyen Duong and Pin-Chuan Chen. 2019. Simple and low-cost production of hybrid 3D-printed microfluidic devices. Biomicrofluidics 13, 2 (2019), 024108.Google Scholar
Cross Ref
- Elveflow. 2019. The Basics of Microfluidic Tubing and Sleeves. https://www.elveflow.com/microfluidic-tutorials/microfluidic-reviews-and-tutorials/microfluidic-fittings-and-tubing-resources/the-basics-of-microfluidic-tubing-sleeves/.Google Scholar
- Stanford Microfluidics Foundry. 2019. Microfluidics Design Rules. https://web.stanford.edu/group/foundry/Basic%20Design%20Rules.html.Google Scholar
- Jonathan L. Gross and Jay Yellen. 2005. Graph Theory and its Applications. Chapman and Hall/CRC.Google Scholar
- Gary D. Hachtel and Fabio Somenzi. 2006. Logic Synthesis and Verification Algorithms. Springer Science 8 Business Media.Google Scholar
- Kai Hu et al. 2017. Control-layer routing and control-pin minimization for flow-based microfluidic biochips. IEEE Trans. CAD 36, 1 (2017), 55--68.Google Scholar
Digital Library
- Mohamed Ibrahim et al. 2017. CoSyn: Efficient single-cell analysis using a hybrid microfluidic platform. In Proc. DATE. 1677--1682.Google Scholar
- Mohamed Ibrahim et al. 2017. Sortex: Efficient timing-driven synthesis of reconfigurable flow-based biochips for scalable single-cell screening. In Proc. ICCAD. 623--630.Google Scholar
- Mais J. Jebrail et al. 2009. Digital microfluidics for automated proteomic processing. Journal of Visualized Experiments: JoVE33 (2009).Google Scholar
- Erik C. Jensen et al. 2007. Micropneumatic digital logic structures for integrated microdevice computation and control. Journal of Microelectromechanical Systems 16, 6 (2007), 1378--1385.Google Scholar
Cross Ref
- Yung-Chun Lei, Chen-Shing Hsu, Juinn-Dar Huang, and Jing-Yang Jou. 2016. Chain-based pin count minimization for general-purpose digital microfluidic biochips. In 2016. ASP-DAC. IEEE, 599--604.Google Scholar
Digital Library
- Wajid H. Minhass et al. 2012. Architectural synthesis of flow-based microfluidic large-scale integration biochips. In Proc. CASES. 181--190.Google Scholar
- Wajid Hassan Minhass, Paul Pop, Jan Madsen, and Tsung-Yi Ho. 2013. Control synthesis for the flow-based microfluidic large-scale integration biochips. In 2013. ASP-DAC. IEEE, 205--212.Google Scholar
Cross Ref
- Kwang W. Oh et al. 2012. Design of pressure-driven microfluidic networks using electric circuit analogy. Lab on a Chip 12, 3 (2012), 515--545.Google Scholar
- Seetal Potluri et al. 2017. Synthesis of on-chip control circuits for mVLSI biochips. In 2017. DATE. IEEE, 1799--1804.Google Scholar
- Michael L. Raagaard and Paul Pop. 2015. Pin count-aware biochemical application compilation for mVLSI biochips. In Proc. DTIP. 1--6.Google Scholar
- Minsoung Rhee and Mark A. Burns. 2009. Microfluidic pneumatic logic circuits and digital pneumatic microprocessors for integrated microfluidic systems. Lab on a Chip 9, 21 (2009), 3131--3143.Google Scholar
- Alexander Schneider et al. 2018. Pin-count reduction for continuous flow microfluidic biochips. Microsystem Technologies 24, 1 (2018), 483--494.Google Scholar
Digital Library
- Alexander Rüdiger Schneider. 2018. Volume Management for Pin-Constrained Continuous-Flow Microfluidic Biochips. Ph.D. Dissertation. Technical University of Denmark.Google Scholar
- Tsun-Ming Tseng et al. 2016. Columba: Co-layout synthesis for continuous-flow microfluidic biochips. In Proceedings of the 53rd Annual Design Automation Conference. ACM, 147.Google Scholar
- Angela R. Wu et al. 2009. Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab on a Chip 9, 10 (2009), 1365--1370.Google Scholar
- Angela R. Wu et al. 2012. High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation. Lab on a Chip 12, 12 (2012), 2190--2198.Google Scholar
- Tao Xu and Krishnendu Chakrabarty. 2008. Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips. In Design Automation Conference, 2008. DAC 2008. 45th ACM/IEEE. IEEE, 173--178.Google Scholar
Digital Library
- Yang Zhao, Tao Xu, and Krishnendu Chakrabarty. 2011. Broadcast electrode-addressing and scheduling methods for pin-constrained digital microfluidic biochips. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 30, 7 (2011), 986--999.Google Scholar
Digital Library
- Ying Zhu et al. 2018. Multi-channel and fault-tolerant control multiplexing for flow-based microfluidic biochips. In Proceedings of the International Conference on Computer-Aided Design. ACM, 123.Google Scholar
Index Terms
Synterface: Efficient Chip-to-World Interfacing for Flow-Based Microfluidic Biochips Using Pin-Count Minimization
Recommendations
Automated design of pin-constrained digital microfluidic arrays for lab-on-a-chip applications*
DAC '06: Proceedings of the 43rd annual Design Automation ConferenceMicrofluidics-based biochips, also referred to as lab-on-a-chip (LoC), are devices that integrate fluid-handling functions such as sample preparation, analysis, separation, and detection. This emerging technology combines electronics with biology to ...
Droplet-routing-aware module placement for cross-referencing biochips
ISPD '10: Proceedings of the 19th international symposium on Physical designDigital Microfluidic Biochip (DMFB) is a revolutionary technology for performing lab-on-a-chip experiments. Comparing to traditional direct-addressing design of DMFB, Cross-Referencing Biochip is a flexible design which not only helps to reduce pin ...
Graphene cantilever-based digital logic gates
AbstractUniversal logic gates NAND and NOR along with NOT and XOR are successfully implemented using graphene cantilever structures. Three-dimensional (3D) modeling of different graphene cantilever structures is carried out using the COMSOL Multiphysics ...






Comments