skip to main content
10.1007/978-3-030-97281-3_7guideproceedingsArticle/Chapter ViewAbstractPublication PagesConference Proceedingsacm-pubtype
Article

MitoDet: Simple and Robust Mitosis Detection

Published:27 September 2021Publication History

Abstract

Mitotic figure detection is a challenging task in digital pathology that has a direct impact on therapeutic decisions. While automated methods often achieve acceptable results under laboratory conditions, they frequently fail in the clinical deployment phase. This problem can be mainly attributed to a phenomenon called domain shift. An important source of a domain shift is introduced by different microscopes and their camera systems, which noticeably change the colour representation of digitized images. In this method description, we present our submitted algorithm for the Mitosis Domain Generalization Challenge [1], which employs a RetinaNet [5] trained with strong data augmentation and achieves an F1 score of 0.7138 on the preliminary test set.

References

  1. 1.Aubreville, M., et al.: Mitosis domain generalization challenge (2021). DOI: https://doi.org/10.5281/zenodo.4573978Google ScholarGoogle Scholar
  2. 2.Cubuk, E.D., Zoph, B., Shlens, J., Le, Q.: RandAugment: practical automated data augmentation with a reduced search space. In: Larochelle, H., Ranzato, M., Hadsell, R., Balcan, M.F., Lin, H. (eds.) Advances in Neural Information Processing Systems, vol. 33, pp. 18613–18624. Curran Associates, Inc. (2020)Google ScholarGoogle Scholar
  3. 3.Ganin Yet al.Domain-adversarial training of neural networksJ. Mach. Learn. Res.2016175913535046191360.68671Google ScholarGoogle ScholarDigital LibraryDigital Library
  4. 4.Li CWang XLiu WLatecki LJDeepMitosis: mitosis detection via deep detection, verification and segmentation networksMed. Image Anal.20184512113310.1016/j.media.2017.12.002Google ScholarGoogle ScholarCross RefCross Ref
  5. 5.Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollar, P.: Focal loss for dense object detection. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2980–2988 (2017)Google ScholarGoogle Scholar
  6. 6.Marzahl Cet al.Deep learning-based quantification of pulmonary hemosiderophages in cytology slidesSci. Rep.2020101979510.1038/s41598-020-65958-2Google ScholarGoogle Scholar
  7. 7.Müller, S.G., Hutter, F.: TrivialAugment: tuning-free yet state-of-the-art data augmentation. In: Proceedings of the IEEE/CVF International Conference on Computer Vision, pp. 774–782 (2021)Google ScholarGoogle Scholar
  8. 8.Smith, L.N., Topin, N.: Super-convergence: very fast training of neural networks using large learning rates. In: Artificial Intelligence and Machine Learning for Multi-Domain Operations Applications, vol. 11006, pp. 369–386. SPIE, May 2019. DOI: https://doi.org/10.1117/12.2520589Google ScholarGoogle Scholar
  9. 9.Sohn, K., Zhang, Z., Li, C.L., Zhang, H., Lee, C.Y., Pfister, T.: A Simple Semi-Supervised Learning Framework for Object Detection. arXiv:2005.04757 [cs], December 2020Google ScholarGoogle Scholar
  10. 10.Stacke KEilertsen GUnger JLundstrom CMeasuring domain shift for deep learning in histopathologyIEEE J. Biomed. Health Inform.202125232533610.1109/JBHI.2020.3032060Google ScholarGoogle Scholar
  11. 11.Tan, M., Le, Q.: EfficientNet: rethinking model scaling for convolutional neural networks. In: Proceedings of the 36th International Conference on Machine Learning, pp. 6105–6114. PMLR, May 2019. ISSN 2640-3498Google ScholarGoogle Scholar
  12. 12.Tellez Det al.Whole-slide mitosis detection in H&E breast histology using PHH3 as a reference to train distilled stain-invariant convolutional networksIEEE Trans. Med. Imaging20183792126213610.1109/TMI.2018.2820199Google ScholarGoogle Scholar
  13. 13.Xie, Q., Luong, M.T., Hovy, E., Le, Q.V.: Self-training with noisy student improves ImageNet classification. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 10687–10698 (2020)Google ScholarGoogle Scholar
  14. 14.Zlocha MDou QGlocker Bet al.Shen Det al.Improving RetinaNet for CT lesion detection with dense masks from weak RECIST labelsMedical Image Computing and Computer Assisted Intervention – MICCAI 20192019ChamSpringer40241010.1007/978-3-030-32226-7_45Google ScholarGoogle ScholarDigital LibraryDigital Library

Index Terms

  1. MitoDet: Simple and Robust Mitosis Detection
          Index terms have been assigned to the content through auto-classification.

          Recommendations

          Comments

          Login options

          Check if you have access through your login credentials or your institution to get full access on this article.

          Sign in
          • Published in

            cover image Guide Proceedings
            Biomedical Image Registration, Domain Generalisation and Out-of-Distribution Analysis: MICCAI 2021 Challenges: MIDOG 2021, MOOD 2021, and Learn2Reg 2021, Held in Conjunction with MICCAI 2021, Strasbourg, France, September 27–October 1, 2021, Proceedings
            Sep 2021
            200 pages
            ISBN:978-3-030-97280-6
            DOI:10.1007/978-3-030-97281-3

            © Springer Nature Switzerland AG 2022

            Publisher

            Springer-Verlag

            Berlin, Heidelberg

            Publication History

            • Published: 27 September 2021

            Qualifiers

            • Article
          • Article Metrics

            • Downloads (Last 12 months)0
            • Downloads (Last 6 weeks)0

            Other Metrics